Post-Docs
Kirsten N. Peters
Current: Feild Scientist at BioTek
B.S. Biology-Molecular Biology and Biotechnology, Missouri State University
Ph.D. Molecular Microbiology and Immunology and Veterinary Pathobiology, University of Missouri
Rossignol ED, Peters KN, Connor JH, Bullitt E. Zika Virus Induced Cellular Remodeling. Cell Microbiol. 2017 Mar 20. doi: 10.1111/cmi.12740.
Claire Marie Filone
Current: Junior PI at NBACC in Fredrick, MD
B.A. Biochemistry and Molecular Biology, Franklin & Marshall College
Ph.D University of Pennsylvania
Filone CM, Hodges EN, Honeyman B, Bushkin GG, Boyd K, Platt A, Ni F, Strom K, Hensley L, Snyder JK,Connor JH. Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach. Chemistry & Biology. 2013 Mar 21;20(3):424-33. doi: 10.1016/j.chembiol.2013.02.011.
Chung DH, Jonsson CB, Tower NA, Chu YK, Sahin E, Golden JE, Noah JW, Schroeder CE, Sotsky JB, Sosa MI, Cramer DE, McKellip SN, Rasmussen L, White EL, Schmaljohn CS, Julander JG, Smith JM, Filone CM, Connor JH, Sakurai Y, Davey RA. Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2. PloS Pathogens. 2014 Jun 26;10(6):e1004213. doi: 10.1371/journal.ppat.1004213. eCollection 2014.
Dan Rozelle
Current: Visiting Scientist in Analytical R&D, Microbiology at Pfizer Inc
B.A. Cellular Biology, California Polytechnic State University
Ph.D Cellular and Developmental Biology, University of California, Davis
Rozelle DK, Filone CM, Kedersha N, Connor JH. Activation of stress response pathways promotes formation of antiviral granules and restricts virus replication. Molecular Cell Biology. 2014 Jun;34(11):2003-16. doi: 10.1128/MCB.01630-13. Epub 2014 Mar 24.
Rozelle DK, Filone CM, Dower K, Connor JH. Vaccinia reporter viruses for quantifying viral function at all stages of gene expression. Journal of Visualized Experiments. 2014 May 15;(87). doi: 10.3791/51522.
Rozelle DK, Filone CM, Kedersha N, Connor JH. Activation of stress response pathways promotes formation of antiviral granules and restricts virus replication. Molecular Cell Biology. 2014 Jun;34(11):2003-16. doi: 10.1128/MCB.01630-13. Epub 2014 Mar 24.
Gammon DB, Duraffour S, Rozelle DK, Hehnly H, Sharma R, Sparks ME, West CC, Chen Y, Moresco JJ, Andrei G, Connor JH, Conte D Jr, Gundersen-Rindal DE, Marshall WL, Yates JR, Silverman N, Mello CC. A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection. eLife. 2014 Jun 25;3. doi: 10.7554/eLife.02910.
Ewan Frazer Dunn
Current: Senior Scientist at Rubius
Ph.D Virology, Glasgow University
Dunn EF, Connor JH. Dominant inhibition of Akt/protein kinase B signaling by the matrix protein of a negative-strand RNA virus. Journal of Virology. 2011 Jan;85(1):422-31. doi: 10.1128/JVI.01671-10. Epub 2010 Oct 27.
Dunn EF, Fearns R, Connor JH. Akt inhibitor Akt-IV blocks virus replication through an Akt-independent mechanism. Journal of Virology. 2009 Nov;83(22):11665-72. doi: 10.1128/JVI.01092-09. Epub 2009 Sep 9.
Ken Dower
Current: Senior Scientist at Phizer
Dower K, Filone CM, Hodges EN, Bjornson ZB, Rubins KH, Brown LE, Schaus S, Hensley LE, Connor JH. Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library. Journal of Virology. 2012 Mar;86(5):2632-40. doi: 10.1128/JVI.05416-11. Epub 2011 Dec 28.
Dower K, Rubins KH, Hensley LE, Connor JH. Development of Vaccinia reporter viruses for rapid, high content analysis of viral function at all stages of gene expression. Antiviral Research. 2011 Jul;91(1):72-80. doi: 10.1016/j.antiviral.2011.04.014. Epub 2011 May 5.
Filone CM, Dower K, Cowley GS, Hensley LE, Connor JH. Probing the virus host interaction in high containment: an approach using pooled short hairpin RNA. ASSAY and Drug Development Technologies. 2015 Jan-Feb;13(1):34-43. doi: 10.1089/adt.2014.613. Epub 2015 Feb 3.
Rozelle DK, Filone CM, Dower K, Connor JH. Vaccinia reporter viruses for quantifying viral function at all stages of gene expression. Journal of Visualized Experiments. 2014 May 15;(87). doi: 10.3791/51522.
Chan WM, Bartee EC, Moreb JS, Dower K, Connor JH, McFadden G. Myxoma and vaccinia viruses bind differentially to human leukocytes. Journal of Virology. 2013 Apr;87(8):4445-60. doi: 10.1128/JVI.03488-12. Epub 2013 Feb 6.
Simpson-Holley M, Kedersha N, Dower K, Rubins KH, Anderson P, Hensley LE, Connor JH. Formation of antiviral cytoplasmic granules during orthopoxvirus infection. Journal of Virology. 2011 Feb;85(4):1581-93. doi: 10.1128/JVI.02247-10. Epub 2010 Dec 8.
Martha Simpson-Holley
Current: Co-Founder Pretty Things Beer and Ales Project
Simpson-Holley M, Kedersha N, Dower K, Rubins KH, Anderson P, Hensley LE, Connor JH. Formation of antiviral cytoplasmic granules during orthopoxvirus infection. Journal of Virology. 2011 Feb;85(4):1581-93. doi: 10.1128/JVI.02247-10. Epub 2010 Dec 8.
Graduate Students
Ignacio S Caballero
Senior Bioinformatics Researcher at Center for Regenerative Medicine, Boston University
B.S. Computer Science, Universidad Pontificia de Salamanca
M.S. Bioinformatics, Universidad Complutense de Madrid
Ph.D Bioinformatics, Boston University
Caballero IS, Yen JY, Hensley LE, Honko AN, Goff AJ, Connor JH. Lassa and Marburg viruses elicit distinct host transcriptional responses early after infection. BMC Genomics. 2014 Nov 6;15:960. doi: 10.1186/1471-2164-15-960.
Connor JH, Yen J, Caballero IS, Garamszegi S, Malhotra S, Lin K, Hensley L, Goff AJ. Transcriptional Profiling of the Immune Response to Marburg Virus Infection. Journal of Virology. 2015 Oct;89(19):9865-74. doi: 10.1128/JVI.01142-15. Epub 2015 Jul 22.
Sara Garamszegi
Current: Program Manager at the Broad Institute
B.S. Biology & Computer Science, University of Miami
Ph.D Bioinformatics, Boston University
Garamszegi S, Yen JY, Honko AN, Geisbert JB, Rubins KH, Geisbert TW, Xia Y, Hensley LE, Connor JH. Transcriptional correlates of disease outcome in anticoagulant-treated non-human primates infected with ebolavirus. PloS Neglacted Tropical Diseases. 2014 Jul 31;8(7):e3061. doi: 10.1371/journal.pntd.0003061. eCollection 2014.
Connor JH, Yen J, Caballero IS, Garamszegi S, Malhotra S, Lin K, Hensley L, Goff AJ. Transcriptional Profiling of the Immune Response to Marburg Virus Infection. Journal of Virology. 2015 Oct;89(19):9865-74. doi: 10.1128/JVI.01142-15. Epub 2015 Jul 22.
Malhotra S, Yen JY, Honko AN, Garamszegi S, Caballero IS, Johnson JC, Mucker EM, Trefry JC, Hensley LE,Connor JH. Transcriptional profiling of the circulating immune response to lassa virus in an aerosol model of exposure. PLOS Neglacted Tropical Diseases. 2013 Apr 25;7(4):e2171. doi: 10.1371/journal.pntd.0002171. Print 2013.
Yen J.Y., Garamszegi S., Geisbert, J.B., Rubins K.H., Geisbert T.W., Xia Y., Connor J.H., Hensley L.E. Therapeutics of Ebola hemorrhagic fever: Whole-genome transcriptional analysis of successful disease mitigation. Journal of Infectious Diseases. In press.
Janos D.P., Garamszegi S., Beltran B.J. Glomalin extraction and measurement. Soil Biology and Biochemistry. 40 (2008): 728-739. doi:10.1016/j.soilbio.2007.10.007
Erin Hodges
Current: Postdoctoral Fellow: CDC
B.S. Molecular Biology, University of Tennessee
Ph.D Microbiology, Boston University
Hodges EN, Heinrich BS, Connor JH. A vesiculovirus showing a steepened transcription gradient and dominant trans-repression of virus transcription. Journal of Virology. 2012 Aug;86(16):8884-9. doi: 10.1128/JVI.00358-12. Epub 2012 Jun 6.
Filone CM, Hodges EN, Honeyman B, Bushkin GG, Boyd K, Platt A, Ni F, Strom K, Hensley L, Snyder JK, Connor JH. Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach. Chemistry & Biology. 2013 Mar 21;20(3):424-33. doi: 10.1016/j.chembiol.2013.02.011.
Dower K, Filone CM, Hodges EN, Bjornson ZB, Rubins KH, Brown LE, Schaus S, Hensley LE, Connor JH. Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library. Journal of Virology. 2012 Mar;86(5):2632-40. doi: 10.1128/JVI.05416-11. Epub 2011 Dec 28.
Filone CM, Hodges EN, Honeyman B, Bushkin GG, Boyd K, Platt A, Ni F, Strom K, Hensley L, Snyder JK, Connor JH. Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach. Chemistry & Biology. 2013 Mar 21;20(3):424-33. doi: 10.1016/j.chembiol.2013.02.011.
Jonathan Lo
B.S. Biology and Bioinformatics, Loyola University Chicago
M.S. in Bioinformatics, Boston University
Lo J, Zhang D, Speranza E, Negron JA, Connor JH. HoTResDB: Host Transcriptional Response Database for Viral Hemorrhagic Fevers. Bioinformatics. 2017 Sep 22. doi: 10.1093/bioinformatics/btx599. [Epub ahead of print]
Deric Zhang
B.S. Physiology and Neurobiology, University of Connecticut
Current: Masters in Bioinformatics Program, Boston University
Lo J, Zhang D, Speranza E, Negron JA, Connor JH. HoTResDB: Host Transcriptional Response Database for Viral Hemorrhagic Fevers. Bioinformatics. 2017 Sep 22. doi: 10.1093/bioinformatics/btx599. [Epub ahead of print]
Laboratory Technicians
Erik Carter
Current: Technician at Genocea
B.S. Pathobiology, University of Connecticut
Carter EP, Seymour EÇ, Scherr SM, Daaboul GG, Freedman DS, Selim Ünlü M, Connor JH. Visualizing Ebolavirus Particles Using Single-Particle Interferometric Reflectance Imaging Sensor (SP-IRIS). Methods Mol Biol. 2017;1628:259-270. doi: 10.1007/978-1-4939-7116-9_21.
Scherr SM, Freedman DS, Agans KN, Rosca A, Carter E, Kuroda M, Fawcett HE, Mire CE, Geisbert TW, Ünlü MS, Connor JH. Disposable cartridge platform for rapid detection of viral hemorrhagic fever viruses. Lab Chip. 2017 Feb 28;17(5):917-925. doi: 10.1039/c6lc01528j.
Judy Yen
Current: Immunology Core, NEIDL
B.S. Molecular Biology, University of California, San Diego
M.S. Virology, University of California, San Diego
Yen JY, Garamszegi S, Geisbert JB, Rubins KH, Geisbert TW, Xia Y, Connor JH, and Hensley LE. “Therapeutics of Ebola hemorrhagic fever: Whole-genome transcriptional analysis of successful disease mitigation.” J Infect Dis., 204 Suppl 3:S1043-52 (2011)
Sanchez V, McElroy AK, Yen JY, Tamrakar S, Clark CL, Schwartz R, and Spector DH. "Cyclin Dependent Kinase Activity is Required at Early Times for Proper Splicing of the HCMV UL122-123 and UL37 Transcripts and at Later Times for Virus Production." J Virol., 78(20):11219-11232 (2004)
Fortunato EA, Sanchez V, Yen JY, and Spector DH. "Infection of Cells with Human Cytomegalovirus during S Phase Results in a Blockade to Immediate-Early Gene Expression That Can Be Overcome by Inhibition of the Proteasome." J. Virol., 76(11):5369-5379 (2002)
Sanchez V, Clark CL, Yen JY, Dwarakanath R, and Spector DH. "Viable Human Cytomegalovirus Recombinant Virus with an Internal Deletion of the IE2 86 Gene Affects Late Stages of Viral Replication." J. Virol., 76(6): 2973-2989 (2002)
Undergraduate Students
Jake Awtry
Current: M.D. Candidate: Johns Hopkins School of Medicine
B.A. Biochemistry & Molecular Biology, Boston University Kilachand Honors College
M.A. Biotechnology, Boston University
Yuying Guo
Current: B.A. Biology, Bryn Mawr College